Aspirin halves risk of women failing from breast cancer

Women in the study who took two to five aspirins a week were far less likely to die from breast cancer or for the cancer to spread

Women with breast cancer who take aspirin at least twice a week canmore than double their chance of surviving, researchers say.

The greatest protection comes from taking the drug two, three, four or five times a week, a study has found.

They cut the risk of dying by 71 per cent and the risk of the cancer spreading by 60 per cent.

Taking aspirin on six or seven days cut the death risk by 64 per cent, but the risk of spreading fell only 43 per cent.

The findings of the U.S. study provide the most compelling evidence yet of the power of the cheap painkiller.

Previous research has suggested that aspirin can protect againstbowel cancer, although results for other cancers, such as breast andprostate, were less clear-cut.

The latest dramatic results came from a 30-year project tracking the health of 238,000 nurses.

Lead researcher Dr Michelle Holmes, of Harvard Medical School,said: "This is the first study to find that aspirin can significantlyreduce the risk of cancer spread and death for women who have beentreated for early-stage breast cancer.

"If these findings are confirmed in other clinical trials,taking aspirin may become another simple, low-cost and relatively safetool to help women with breast cancer live longer, healthier lives."

Drugs in the same class as aspirin, including ibuprofen and naproxen, also lowered the risks, but paracetamol did not.

Expertswarned, however, that aspirin can have serious side effects, includingstomach irritation that can lead to ulcers and even fatal bleeding.

For some people the risk of harm is greater than potential benefits.

Women newly diagnosed with breast cancer are advised not to takeaspirin for the first 12 months as it can cause side effects while theyundergo chemotherapy or radiation.

Researchers are uncertain exactly how aspirin affects tumoursbut it could be by lowering inflammation. The study found that therewere no beneficial effects for people who took aspirin only once aweek.

Despite its benefits, many cancer sufferers could also find themselves struggling with severe side effects if they take aspirin regularly

Dr Holmes said: "Aspirin cannot be considered a substitute forconventional cancer treatments, and taking aspirin does have negativeeffects in some.

"More study is definitely needed toestablish the cause and effect of aspirin on breast cancer. But fornow, if a woman has breast cancer and is taking aspirin, she may takesome comfort in knowing she might be doing something to help preventher breast cancer from recurring."

Millions of people in the UK already take low-dose aspirinevery day on doctor"s advice to reduce the chance of a repeat heartattack or stroke.

Others take it of their own accord for "health insurance".

Most of the women in the new study, published in the Journal ofClinical Oncology, were taking aspirin to prevent heart disease.

The Harvard team identified 4,000 breast cancer patientsbetween 1976 and 2002 and followed them until their deaths or the endof the study in June 2006.

Altogether 341 women died from the cancer.

The Harvard study falls short of the research "goldstandard", however, because the women reported their aspirin use inquestionnaires, rather than going through a controlled clinical trial.

The next stage of drug development would normally be a large randomised study, but this may never happen.

Not only is aspirin so cheap it will not make any money for drugfirms, it could be hard to find a group of women with breast cancer whowere prepared never to take aspirin during a trial.

Nick Henderson of the European Aspirin Foundation, whichrepresents the industry, said: "The best evidence for aspirin inprotecting against cancer has been from studies on bowel cancer.

"But this latest report adds to growing evidence that aspirinappears to have special effects in reducing cancer risk through amechanism which has yet to be scientifically explained.

"However,I doubt it will be possible to carry out a proper clinical trialbecause everyone has heard aspirin may be useful. We"re going to hold aconference to plan the way forward."

Ed Yong, head of health information at Cancer Research UK,said: "Several studies have found that taking aspirin and related drugsis associated with a lower risk of breast cancer, and this new studysuggests that they might also help to stop cancer from spreading andimprove a woman"s chances of survival.

"But aspirin has risks as well as benefits, so we need largeclinical trials to see if it can really save lives from breast cancer,and, if so, to work out what doses to use and how long to use the drugsfor."

SIX NATIONS 2010: Italy twelve England seventeen - Martin Johnsons side freeze up as shy infantry return to ping-pong in Italian shock

England confirmed their winning begin to this season"s RBS Six Nations, but that is the sum total of the great news. This was the day when fright seized Martin Johnson"s group in the gloomy hold once more.

The discreet idea of Twickenham eight days progressing - when there were enlivening signs of revival, 3 tries and feat in the face of a Welsh fightback - gave approach to a bold awakening in the Italian capital.

This gloomy compare and tedious opening from the England group was a sign that they are majority a mile from being a manly force, let alone the accomplished article.

Breakthrough: Mathew Tait breaks the Italian counterclaim for the usually try of the game

MATCH FACTS

ITALY: L McLean; A Masi (K Robertson 58-68min), G Canale, G Garcia (K Robertson 80), Mirco Bergamasco; C Gower, T Tebaldi (P Canavosio 56); S Perugini (M Aguero 56), L Ghiraldini (capt, F Ongaro 80), M Castrogiovanni; Q Geldenhuys, M Bortolami; J Sole (S Perugini 65-76), A Zanni, Mauro Bergamasco.Sin-bin: Castrogiovanni.ENGLAND: D Armitage; M Cueto, M Tait, R Flutey, U Monye; J Wilkinson, D Care(P Hodgson 80); T Payne (M Mullan 63),D Hartley (S Thompson 76), D Cole(D Wilson 70); S Shaw (L Deacon 70),S Borthwick (capt); J Haskell, N Easter,L Moody (S Armitage 80).

Referee: Christophe Berdos (France).

Having taken a indeterminate step forwards at home, they soon took 4 or five retrograde here. This was a feat for a side systematic by Johnson and hermetic by a right-footed dump idea from Jonny Wilkinson, but there the similarities with the 2003 World Cup last delight over Australia at once end.

Back then, England were a hold up section awash with self-confidence. On this evidence, the category of 2010 are so moving and shy as to be fearful of their own shadows. Either that, or they are being systematic to keep personification as if the weight of the universe is on them.

In the failing mins at the Stadio Flaminio, Wilkinson knocked over his ultimate dump idea with worthy fluency, since the approach he had kicked until that stage. Behind the posts, fans in English white cavorted in celebration, but their reactions were innate of relief, not feeling of well-being or triumphalism.

That changed set upon took the sting out of an Italian reconstruction after thehosts had progressively realised that they could do some-more than only containtheir presumably higher opponents, they could conflict them.

Nowhere to hide: Wilkinson"s countenance spoke volumes at the last whistle

Once the Azzurri had cottoned on to the actuality that England were vigilant on kicking afar any value they had, they proposed branch the screw and roughly pulled off a vital upset.

Two Mirco Bergamasco penalties took Italy inside of range of feat at 12-14 with 7 mins left and the throng stirring up a charge of sound as they sensed story in the making.

Negative tactics: England physical education instructor Martin Johnson

England showed only sufficient restraint to expostulate strongly on the right from a lineout and after James Haskell had battered on in to the 22, Wilkinson eased in to a informed slight - dump behind in to the pocket, take the pass, take target and fire.

Yet Italian tails were up and they kept coming, forcing Johnson"s rattled group to adhere on, meaningful one fake move would throw it all away.

So they belligerent it out and, from a scrum on the left, deputy scrum half Paul Hodgson upheld left for Delon Armitage to flog the round out and finish the agony. It was a suitably handicapped culmination and the crescendo of boos that tumbled down from the stands represented so majority satisfactory comment.

This should never have come down to a print finish. It should have been a horribly biased affair. Italy, with no genuine Test-class backs, were calm - as ever - to foot the round afar and solve for scrapping and paltry and harrying and hoping.

They used their strong pack to pressurise England at the breakdown. Their forwards, Alessandro Zanni and Marco Bortolami being the majority prominent, gave them pushing momentum.

But England played in to their hands by permitting counsel to empty the certainty gained from that critical win over Wales. Far as well often, they over behind in to the horrible settlement that scarred their autumn array - if in doubt, punt. Anywhere will do. It was aimless, horrible and definitely ineffective.

It was witless ping-pong. At Twickenham, Danny Care"s accurate box-kicks had worried the Welsh and set a height for so majority of England"s attacks.

Here, Wilkinson - often - but additionally Riki Flutey, Mat Tait, Mark Cueto, Ugo Monye and Armitage kicked long. But they kicked to men, not to space, and but the fill-in of a strong, mutual chase.

England hold the top palm at the lineout but there weren"t sufficient touch-finders to feat that Italian weakness.

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Pensioner attempted murder related to Manchester car play ground suicide

Simon Alford & , : {}

The attempted attempted attempted murder of a licentiate in her home has been associated to the genocide of a man who fell from the roof tiles tiles of a multi-storey car play ground thirty miles away, detectives have said.

The 69-year-old lady was found with gash wounds inside her semi-detached one-story dwelling in the Bradley area of Huddersfield, West Yorkshire, yesterday dusk and after died from her injuries.

Blood could be seen dirty on the white front doorway of the semi-detached home, that stays cordoned off.

A 37-year-old man, who was additionally stabbed at the house, stays in hospital, but his condition is not thought to be hold up threatening.

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Michael Hunt, 46, an RAC man, conspicuous his son found a blade edge close to the scene.

He said: It had a blade edge about 6 inches long. The military came down and afterwards cordoned all off and it has been sealed all night.

He was shocked, obviously, but he was blissful he had been means to do something. He watches CSI so he knew not to hold the knife.

Detectives in West Yorkshire, who conspicuous they were questioning a "domestic associated incident", have right away associated the attempted attempted attempted murder with the genocide of a man in Manchester.

A physique was found at the bottom of an eight-floor car play ground in the city centre only after midnight.

A West Yorkshire Police orator said: Detectives questioning the attempted attempted attempted murder of a lady in Huddersfield yesterday are liaising with Greater Manchester Police after a man was found passed in Manchester city centre early today.

Shortly after midnight, the physique of a man was found at a multi-storey car play ground in Hanover Street. It is believed he had depressed from the roof.

He was conspicuous passed at the stage and a post mortem is approaching to take place after today. The genocide is not believed to be suspicious."

Officers questioning the stabbing have conspicuous it was a "targeted attack".

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British planespotters confronting 3 years in an Indian prison

Jeremy Page, Delhi & , : {}

Two British planespotters incarcerated in Delhi could face up to 3 years in jail after they were charged with illegally intercepting communications in between pilots and airfield authorities.

Stephen Hampton, 46, and Steven Ayres, 56, were incarcerated last Monday at the Radisson hotel, nearby Delhis general airport, after staff grew questionable and contacted police.

The dual railway workers from Bristol had requested a room unaware the depot and military found them in receive of a map of the airport, a air wave scanner, cameras and binoculars, according to internal media reports.

The Radisson is referred to as one of the most appropriate places in the Indian collateral to watch planes on the website plane-spotting-hotels.com.

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The span were questioned in the road house by the Intelligence Bureau, Delhi military and the National Investigation Agency for dual days, afterwards sent to the Lampur apprehension centre only outward Delhi. The British High Commission told The Times they had been charged underneath the IndianAct, that regulates the make use of of telecommunications equipment, and were being supposing with consular assistance.

Rajan Bhagat, a orator for Delhi police, said: This planespotting that they were you do is bootleg in India. They should have practical for accede prior to you do this.

They are not suspected of impasse with militant groups and are set to be bailed in the subsequent couple of days, but they could still face up to 3 years in jail if they are convicted.

Their detain came as India was on high rapt after a explosve explosion in the city of Poona on Feb 13, that killed twelve people together with dual foreigners. It was the largest such conflict given the Mumbai slaughter of Nov 2008.

It is not the initial time British planespotters have damaged the law overseas: in 2000, twelve were arrested in Greece for monitoring planes at an Air Force Day function. They were charged with spying and faced 20-year jail conditions but after 6 weeks the charges were marked down and they were expelled tentative appeals.

Mr Hamptons mother, Eileen Cock, pronounced her son had trafficked the universe photographing aircraft and had never prior to run in to authorised trouble. We unequivocally have no thought what is going to occur right away we are only watchful with bated breath, she said.

Mr Ayress eldest daughter, Katy, 23, spoke to her father yesterday. Hes a bit emotional, she told The Times. Its a service to listen to his voice.

Gordon Brown contingency discuss it me because my son had to die Susan Smith

Susan Smith & , : {}

When Gordon Brown sits down in front of the Chilcot exploration today, there is one issue that I wish him to be confronted with: my son, Phillip, was killed by a roadside explosve in Iraq. With dual alternative colleagues who died, he was in a simply armoured Snatch Land Rover. You were Chancellor at the time, Mr Brown, holding the purse strings, so because wasnt income outlayed on removing the right equipment? You had to be wakeful of what was happening. You had responsibility. So because were those unsound vehicles used?

Mr Brown knew that Tony Blair was going to go to war, no make a difference what. But everybody knows you have to be rebuilt to go to war. You wouldnt send a fireman in to a blazing residence with no hose, afterwards consternation because he died. So because should soldiers be any different?

But instead of answers, we are removing spin. Mr Brown will usually contend what he feels he can get afar with. Politicians fool around to the gallery. Of march I would similar to him to suggest an apology, but that is not going to happen.

This finish warding off to understanding with the disaster to yield soldiers with life-protecting apparatus has done me lose any apply oneself I had for MPs. I have simply lost my certitude in them. I was at the Chilcot exploration when Mr Blair gave evidence. It was similar to examination a showman, watchful for the applause. I additionally met the people using the exploration I favourite and reputable them but Im not awaiting them to remove any answers today. If Mr Brown is anything similar to Mr Blair it will be usually waffle.

BACKGROUND"I"m so angry. I wish answers"Helmand dried unprotected Snatchs shortcomingsSoldiers liberation section using out of space

The domestic category wish an exploration in to all solely what is critical Bob Ainsworth, the Defence Secretary, motionless that it was not suitable to have an exploration in to the deaths of soldiers . We, the kin of the soldiers who died, feel utterly cut off from the people in Westminster. Take the bitch about Lord Ashcroft: what on earth is the aptitude to typical people of either he paid his taxes when you have a genuine issue here the unnecessary deaths of soldiers? The people in Westminster arent usually vital in a bubble; theyre on an additional planet.

Phillip was my usually son. He gave 3 years to the Army and he usually lived for 21. But the not usually about me and him; the additionally about the alternative 36 servicemen and women who lost their lives. What I and all the kin need to know is because were they authorised to die in these Snatch Land Rovers.

Ministers knew about these mobile coffins but they used them anyway. If the MoD was a business, it would have been closed. Its over a joke. Its an insult. So most lives could have simply been saved if a couple of some-more people in energy had asked untimely questions. And got answers.

Susan Smiths son, Private Phillip Hewett, of the 1st Battalion Staffordshire Regiment, died on Jul 16, 2005. He was 21